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Nervous System Dysregulation as a Major Factor in Disease: A Comparative Review in Humans and Horses

The nervous system acts as the body’s master control center, regulating stress, digestion, cardiovascular function, and recovery. When this system becomes dysregulated—stuck in “fight-or-flight” mode or unable to return to rest—it can drive disease rather than simply respond to it. In humans, nervous system imbalance is linked to chronic pain, cardiovascular disease, and stress-related disorders. In horses, it plays a central role in equine grass sickness, age-related conditions like PPID, and performance or behavior issues. Across species, the evidence is clear: nervous system balance is not optional, but essential to health.

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